Toxicoepigenetics
  • Author : Shaun D. McCullough
  • Release Date : 02 November 2018
  • Publisher : Academic Press
  • Genre : Medical
  • Pages : 428
  • ISBN 13 : 9780128124345

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Book excerpt: Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study. Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications

Toxicoepigenetics

Toxicoepigenetics

Author : Shaun D. McCullough,Dana Dolinoy
Publisher : Academic Press
Genre : Medical
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Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken ...

Translational Toxicology and Therapeutics

Translational Toxicology and Therapeutics

Author : Michael D. Waters,Claude L. Hughes
Publisher : John Wiley & Sons
Genre : Health & Fitness
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Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new ...

Pharmacoepigenetics

Pharmacoepigenetics

Author : Anonim
Publisher : Academic Press
Genre : Medical
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Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the ...

Toxicology and Epigenetics

Toxicology and Epigenetics

Author : Saura C. Sahu
Publisher : John Wiley & Sons
Genre : Science
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Epigenetics is the study of both heritable and non-heritablechanges in the regulation of gene activity and expression thatoccur without an alteration in the DNA sequence. Thisdynamic and rapidly developing discipline is making its impactacross the biomedical sciences, in particular in toxicology whereepigenetic differences can mean that different individuals responddifferently to ...

Personalized Epigenetics

Personalized Epigenetics

Author : Trygve Tollefsbol
Publisher : Academic Press
Genre : Science
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Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and ...

Translational Toxicology and Therapeutics

Translational Toxicology and Therapeutics

Author : Michael D. Waters,Claude L. Hughes
Publisher : John Wiley & Sons
Genre : Medical
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Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new ...

Pharmacokinetics and Toxicokinetic Considerations   Vol II

Pharmacokinetics and Toxicokinetic Considerations Vol II

Author : Rakesh Kumar Tekade
Publisher : Academic Press
Genre : Business & Economics
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Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the ...

Pharmacoepigenetics

Pharmacoepigenetics

Author : Anonim
Publisher : Academic Press
Genre : Medical
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Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the ...

Aminoglycosides  Advances in Research and Application  2011 Edition

Aminoglycosides Advances in Research and Application 2011 Edition

Author : Anonim
Publisher : ScholarlyEditions
Genre : Medical
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Aminoglycosides: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Aminoglycosides in a compact format. The editors have built Aminoglycosides: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Aminoglycosides in ...

Epigenetics Methods

Epigenetics Methods

Author : Trygve Tollefsbol
Publisher : Academic Press
Genre : Medical
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In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools ...

HiC Pro  an Optimized and Flexible Pipeline for Hi C Data Processing

HiC Pro an Optimized and Flexible Pipeline for Hi C Data Processing

Author : Oldenburg Oldenburg Press
Publisher : Unknown
Genre : Uncategorized
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HiC-Pro is an optimized and flexible pipeline for processing Hi-C data from raw reads to normalized contact maps. HiC-Pro maps reads, detects valid ligation products, performs quality controls and generates intra- and inter-chromosomal contact maps. It includes a fast implementation of the iterative correction method and is based on a ...

Nutritional Epigenomics

Nutritional Epigenomics

Author : Anonim
Publisher : Academic Press
Genre : Medical
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Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in ...

Drug Metabolism

Drug Metabolism

Author : Katherine Dunnington
Publisher : BoD – Books on Demand
Genre : Medical
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Drug metabolism comprises the identification, characterization, and quantification of the chemicals or compounds produced in an animal or human upon administration of a drug. Research practices not only require the chemical structure but also aim to determine the pharmacological activities and/or toxicity of these compounds. This is first performed ...

Histone Modifications in Therapy

Histone Modifications in Therapy

Author : Pedro Castelo-Branco,Carmen Jeronimo
Publisher : Academic Press
Genre : Science
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Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant ...

Alzheimer s Disease Drug Development

Alzheimer s Disease Drug Development

Author : Jeffrey Cummings,Jefferson Kinney,Howard Fillit
Publisher : Cambridge University Press
Genre : Medical
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Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models....