Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders
  • Author : Lucia Morbidelli
  • Release Date : 09 February 2019
  • Publisher : Academic Press
  • Genre : Medical
  • Pages : 372
  • ISBN 13 : 9780128172797

Download Or Read Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders eBook PDF

Book excerpt: Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Author : Lucia Morbidelli,Benjamin Bonavida
Publisher : Academic Press
Genre : Medical
Get Book

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various ...

Nitric Oxide  NO  and Cancer

Nitric Oxide NO and Cancer

Author : Benjamin Bonavida
Publisher : Springer
Genre : Medical
Get Book

Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important ...

Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy

Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy

Author : Anonim
Publisher : Academic Press
Genre : Science
Get Book

Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book ...

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

Author : Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
Publisher : Springer Science & Business Media
Genre : Medical
Get Book

The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the ...

Inflammation in the Pathogenesis of Chronic Diseases

Inflammation in the Pathogenesis of Chronic Diseases

Author : Randall E. Harris
Publisher : Springer Science & Business Media
Genre : Medical
Get Book

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future ...

Chemokine Biology   Basic Research and Clinical Application

Chemokine Biology Basic Research and Clinical Application

Author : Gordon L. Letts
Publisher : Springer Science & Business Media
Genre : Medical
Get Book

Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes ...

Nitric Oxide Donors

Nitric Oxide Donors

Author : Amedea Seabra
Publisher : Academic Press
Genre : Medical
Get Book

Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain ...

Organic Nitrates

Organic Nitrates

Author : P. Needleman
Publisher : Springer Science & Business Media
Genre : Medical
Get Book

Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease ...

WHO Guidelines for Indoor Air Quality

WHO Guidelines for Indoor Air Quality

Author : World Health Organization
Publisher : World Health Organization
Genre : House & Home
Get Book

This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, ...

The Physiology of Inflammation     The Final Common Pathway to Disease

The Physiology of Inflammation The Final Common Pathway to Disease

Author : Alexandrina Ferreira Mendes,Maria Teresa Cruz,Oreste Gualillo
Publisher : Frontiers Media SA
Genre : Uncategorized
Get Book

Chronic diseases are increasingly recognized as involving low grade inflammation, that is, a self-perpetuating tissue response to stress caused by exogenous or endogenous triggers, that progressively evokes danger-associated molecular pattern release, ultimately driving tissue damage and loss of function. This response is frequently unapparent clinically, thus the designation "low grade". ...

Adhesion Molecules  Function and Inhibition

Adhesion Molecules Function and Inhibition

Author : Klaus Ley
Publisher : Springer Science & Business Media
Genre : Medical
Get Book

Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders ...

The Hereditary Basis of Rheumatic Diseases

The Hereditary Basis of Rheumatic Diseases

Author : Rikard Holmdahl
Publisher : Springer Science & Business Media
Genre : Medical
Get Book

Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part deals with the shared ...

Regulation of Inducible Nitric Oxide Synthase Expression in Human Cells

Regulation of Inducible Nitric Oxide Synthase Expression in Human Cells

Author : Martin Lee
Publisher : Unknown
Genre : Uncategorized
Get Book

Nitric oxide (NO) is a bioactive gas that has multiple roles in innate and adaptive immune responses and dysregulated expression of its production by inducible nitric oxide synthase (iNOS) is implicated in the pathogenesis of various inflammatory diseases and cancer. The mechanisms by which the expression of iNOS is regulated ...

Toll like Receptors in Inflammation

Toll like Receptors in Inflammation

Author : Luke A.J. O'Neill,Elizabeth Brint
Publisher : Springer Science & Business Media
Genre : Medical
Get Book

A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA ...

Food Factors for Health Promotion

Food Factors for Health Promotion

Author : Toshikazu Yoshikawa
Publisher : Karger Medical and Scientific Publishers
Genre : Medical
Get Book

Food factors are considered to be critical for human health promotion and play an important role in the prevention of life-style related diseases. One of the major challenges in this context is to determine the multiple factors associated with the causes of these diseases, as well as to develop a ...