The Epigenetics of Autoimmunity
  • Author : Rongxin Zhang
  • Release Date : 25 April 2018
  • Publisher : Academic Press
  • Genre : Medical
  • Pages : 432
  • ISBN 13 : 9780128099285

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Book excerpt: The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment. Provides the accurate and cutting-edge information on autoimmunity epigenetics Wide coverage appeals to those interested in fundamental epigenetics and inheritance to those with more clinical interests Critical reviews of the mean of deriving and analysing autoimmunity epigenetics information as well as its translational potential Up-to-date coverage of emerging topics in autoimmunity epigenetics

The Epigenetics of Autoimmunity

The Epigenetics of Autoimmunity

Author : Rongxin Zhang
Publisher : Academic Press
Genre : Medical
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The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic ...

The Epigenetics of Autoimmune Diseases

The Epigenetics of Autoimmune Diseases

Author : Moncef Zouali
Publisher : John Wiley & Sons
Genre : Medical
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The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this ...

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity

Author : Christopher Chang,Qianjin Lu
Publisher : Springer Nature
Genre : Medical
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This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – ...

Epigenetics of the Immune System

Epigenetics of the Immune System

Author : Dieter Kabelitz,Jaydeep Bhat
Publisher : Academic Press
Genre : Medical
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Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, ...

Epigenetic Drug Discovery

Epigenetic Drug Discovery

Author : Wolfgang Sippl,Manfred Jung
Publisher : John Wiley & Sons
Genre : Medical
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This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any ...

Epigenetics in Human Disease

Epigenetics in Human Disease

Author : Trygve O. Tollefsbol
Publisher : Academic Press
Genre : Medical
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Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of ...

Mosaic of Autoimmunity

Mosaic of Autoimmunity

Author : Carlo Perricone,Yehuda Shoenfeld
Publisher : Academic Press
Genre : Medical
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The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors ...

Epigenetics and Dermatology

Epigenetics and Dermatology

Author : Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
Publisher : Academic Press
Genre : Science
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Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages ...

Prognostic Epigenetics

Prognostic Epigenetics

Author : Anonim
Publisher : Academic Press
Genre : Medical
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This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for ...

Computational Epigenetics and Diseases

Computational Epigenetics and Diseases

Author : Anonim
Publisher : Academic Press
Genre : Business & Economics
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Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, ...

DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease

Author : Michel Neidhart
Publisher : Academic Press
Genre : Science
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DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as ...

Translational Studies on Inflammation

Translational Studies on Inflammation

Author : Ane C.F. Nunes
Publisher : BoD – Books on Demand
Genre : Medical
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Inflammation is known worldwide, from the bench to the bedside, but it is a hard theme to approach with one single point of view.In this sense, a selection of translational studies would support the medical-scientific community to better understand the complex network of the inflammatory process, its maintenance, and ...

Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics

Author : Shuai Li,John Hopper
Publisher : Academic Press
Genre : Medical
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Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and ...

Personalized Epigenetics

Personalized Epigenetics

Author : Trygve Tollefsbol
Publisher : Academic Press
Genre : Science
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Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and ...

The Value of BCG and TNF in Autoimmunity

The Value of BCG and TNF in Autoimmunity

Author : Denise Faustman
Publisher : Academic Press
Genre : Medical
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The Value of BCG and TNF in Autoimmunity provides an overview of current research and thinking related to tumor necrosis factor (TNF) induction and the use of the bacillus Calmette-Guérin (BCG) vaccine as potential treatment approaches to diverse forms of autoimmunity. BCG, commonly known as an anti-tuberculosis vaccine, is ...