Research in the Biomedical Sciences
  • Author : Michael Curtis
  • Release Date : 01 June 2017
  • Publisher : Academic Press
  • Genre : Uncategorized
  • Pages : 356
  • ISBN 13 : 0128047259

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Book excerpt: Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences. Provides a "big picture" perspective that includes the scope of the replicability issue and covers initiatives that have the potential to act as effective solutions Offers real world research context for transparent, replicable experimental design and execution and reporting of biomedical research with the potential to address aspects of the translational gap in drug discovery Highlights the importance of reproducibility and the necessary changes in biomedical and pharmaceutical research training and incentives to ensure sustainability

Research in the Biomedical Sciences

Research in the Biomedical Sciences

Author : Michael Curtis,Michael Williams
Publisher : Academic Press
Genre : Uncategorized
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Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived ...

Reproducibility and Replicability in Science

Reproducibility and Replicability in Science

Author : National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Board on Research Data and Information,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Reproducibility and Replicability in Science
Publisher : National Academies Press
Genre : Science
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One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of ...

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health,National Cancer Policy Forum,Forum on Neuroscience and Nervous System Disorders,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Genre : Medical
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Sharing knowledge is what drives scientific progress - each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their ...

Implementing Reproducible Research

Implementing Reproducible Research

Author : Victoria Stodden,Friedrich Leisch,Roger D. Peng
Publisher : CRC Press
Genre : Mathematics
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In computational science, reproducibility requires that researchers make code and data available to others so that the data can be analyzed in a similar manner as in the original publication. Code must be available to be distributed, data must be accessible in a readable format, and a platform must be ...

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health,National Cancer Policy Forum,Forum on Neuroscience and Nervous System Disorders,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Genre : Medical
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Sharing knowledge is what drives scientific progress - each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their ...

Reproducible Research with R and RStudio

Reproducible Research with R and RStudio

Author : Christopher Gandrud
Publisher : CRC Press
Genre : Business & Economics
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Praise for previous editions: "Gandrud has written a great outline of how a fully reproducible research project should look from start to finish, with brief explanations of each tool that he uses along the way... Advanced undergraduate students in mathematics, statistics, and similar fields as well as students just beginning ...

Reproducibility in Biomedical Research

Reproducibility in Biomedical Research

Author : Erwin B. Montgomery
Publisher : Academic Press
Genre : Medical
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Reproducibility in Biomedical Research: Epistemological and Statistical Problems explores the ideas and conundrums inherent in scientific research. It explores factors of reproducibility, including logic, distinguishing productive from unproductive irreproducibility, the scientific method, and the use of statistics. In multiple examples and six detailed case studies, the book demonstrates the misuse ...

Rigor Mortis

Rigor Mortis

Author : Richard Harris
Publisher : Basic Books
Genre : Medical
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"A rewarding read for anyone who wants to know the unvarnished truth about how science really gets done."--Financial Times American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't ...

Experimental Design for Laboratory Biologists

Experimental Design for Laboratory Biologists

Author : Stanley E. Lazic
Publisher : Cambridge University Press
Genre : Family & Relationships
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A guide to designing lab-based biological experiments that have low bias, high precision and widely applicable results....

Good Research Practice in Non Clinical Pharmacology and Biomedicine

Good Research Practice in Non Clinical Pharmacology and Biomedicine

Author : Anton Bespalov,Martin C. Michel,Thomas Steckler
Publisher : Springer Nature
Genre : Cardiology
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This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine....

Fostering Integrity in Research

Fostering Integrity in Research

Author : National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Committee on Responsible Science
Publisher : National Academies Press
Genre : Science
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The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the ...

The Practice of Reproducible Research

The Practice of Reproducible Research

Author : Justin Kitzes,Daniel Turek,Fatma Deniz
Publisher : Univ of California Press
Genre : Science
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The Practice of Reproducible Research presents concrete examples of how researchers in the data-intensive sciences are working to improve the reproducibility of their research projects. In each of the thirty-one case studies in this volume, the author or team describes the workflow that they used to complete a real-world research ...

Experimental Design and Reproducibility in Preclinical Animal Studies

Experimental Design and Reproducibility in Preclinical Animal Studies

Author : José M. Sánchez Morgado,Aurora Brønstad
Publisher : Springer
Genre : Medical
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This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, ...

Introduction to the Responsible Conduct of Research  rev  Ed

Introduction to the Responsible Conduct of Research rev Ed

Author : Nicholas H. Steneck
Publisher : DIANE Publishing
Genre : Uncategorized
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This report seeks to supplement existing resources by making a comprehensive overview of basic rules of the road for responsible research available to all U.S. Public Health Service-funded researchers. It has been prepared with the needs of small and mid-size research and institutions and beginning researchers in mind, but ...