Fibroblast Growth Factor 23
  • Author : Christian Faul
  • Release Date : 06 April 2021
  • Publisher : Elsevier
  • Genre : Medical
  • Pages : 376
  • ISBN 13 : 9780128180372

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Book excerpt: Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23. Provides a comprehensive collection of chapters on the diversity of FGF23's actions Highlights truly translational topics, from molecular signaling to physiology and mechanism of disease, discussing cell culture and animal models to study FGF23 Describes FGF23’s potential in the clinical setting as a biomarker or even drug target Presents leaders in the field who cover a wide spectrum of research backgrounds and expertise, including clinical and basic scientists who specialize in diseases, endocrinology, genetics, protein biochemistry, cell biology and physiology

Fibroblast Growth Factor 23

Fibroblast Growth Factor 23

Author : Christian Faul,Kenneth White,Orlando Gutierrez
Publisher : Elsevier
Genre : Medical
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Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived ...

Phosphate Metabolism

Phosphate Metabolism

Author : Shaul Massry
Publisher : Springer Science & Business Media
Genre : Medical
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We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days ...

Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease

Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease

Author : Reinhold G. Erben,L. Darryl Quarles
Publisher : Frontiers Media SA
Genre : Uncategorized
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αKlotho and fibroblast growth factor-23 (FGF23) were discovered independently about 20 years ago. Since their initial description, a series of exciting discoveries have revealed the important role of endocrine and paracrine FGF23 and αKlotho signaling not only for the physiological regulation of mineral and bone homeostasis, but also for the pathophysiology ...

Recent Advances in Dialysis Therapy in Japan

Recent Advances in Dialysis Therapy in Japan

Author : H. Nakamoto,K. Nitta,K. Tsuchiya,H. Okada,H. Hasegawa
Publisher : Karger Medical and Scientific Publishers
Genre : Medical
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The number of dialysis patients, and their ages, continues to increase globally. This creates major issues such as rising medical costs in an aging population, how to best manage end-of-life care, and how to train the various practitioners involved in dialysis care. After the US and China, Japan occupies 3rd ...

Endocrine FGFs and Klothos

Endocrine FGFs and Klothos

Author : Makoto Kuro-o
Publisher : Springer Science & Business Media
Genre : Science
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Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, ...

Phosphate and Vitamin D in Chronic Kidney Disease

Phosphate and Vitamin D in Chronic Kidney Disease

Author : M.S. Razzaque
Publisher : Karger Medical and Scientific Publishers
Genre : Medical
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The enormous progress made during the last decade has resulted in a better conceptual understanding of mineral ion metabolism in general. With regard to chronic kidney disease, the two most affected nutrients are phosphate and vitamin D. This book provides an overview of the physiological aspects of phosphate and vitamin ...

Biomarkers of Kidney Disease

Biomarkers of Kidney Disease

Author : Charles L. Edelstein
Publisher : Academic Press
Genre : Science
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Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book. This comprehensive book details the latest advances made in ...

Pediatric Nephrology

Pediatric Nephrology

Author : Ellis D. Avner,William E. Harmon,Patrick Niaudet,Norishige Yoshikawa
Publisher : Springer Science & Business Media
Genre : Medical
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Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by ...

Translational Endocrinology of Bone

Translational Endocrinology of Bone

Author : Gerard Karsenty
Publisher : Academic Press
Genre : Medical
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The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in ...

Diseases of the Kidney and Urinary Tract

Diseases of the Kidney and Urinary Tract

Author : Robert W. Schrier
Publisher : Lippincott Williams & Wilkins
Genre : Medical
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The thoroughly updated Eighth Edition of this classic three-volume work provides the most comprehensive, current, and authoritative information on diseases of the kidney and urinary tract. This clinically oriented reference focuses on diagnosis and treatment of specific diseases, disorders, and complications and incorporates the basic science practicing physicians need to ...

Chronic Kidney Disease

Chronic Kidney Disease

Author : Thomas Rath
Publisher : BoD – Books on Demand
Genre : Medical
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Known worldwide, chronic kidney disease (CKD) is a disease that affects up to 4% of the population with increasing figures also in the developing countries. Life expectancy of patients affected by CKD is shortened compared to the overall population, and only a minority of patients reach end-stage renal disease (ESRD) with ...

ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Author : Anonim
Publisher : John Wiley & Sons
Genre : Science
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EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is ...

Calcium and Bone Disorders in Children and Adolescents

Calcium and Bone Disorders in Children and Adolescents

Author : J. Allgrove,N.J. Shaw
Publisher : Karger Medical and Scientific Publishers
Genre : Medical
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There has been a rapid expansion of knowledge in the field of paediatric calcium and bone disorders over the past twenty years. Advances have been made in the underlying genetic basis for many conditions in conjunction with progress in bone density and geometry imaging and the development of new treatment ...

Brush Border Membranes

Brush Border Membranes

Author : Ruth Porter,Geralyn M. Collins
Publisher : John Wiley & Sons
Genre : Medical
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The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known ...

Hypoparathyroidism

Hypoparathyroidism

Author : Maria Luisa Brandi,Edward Meigs Brown
Publisher : Springer
Genre : Medical
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Hypoparathyroidism, a condition in which insufficient parathyroid hormone (PTH) is produced to maintain normocalcemia is associated with a variety of acute and chronic symptoms and complications due to hypocalcemia. Replacement therapy utilizing PTH has long been awaited, and this book is new and very timely as it coincides with the ...