Epigenetic Cancer Therapy
  • Author : Steven Gray
  • Release Date : 01 July 2015
  • Publisher : Academic Press
  • Genre : Medical
  • Pages : 748
  • ISBN 13 : 9780128002247

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Book excerpt: Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs

Epigenetic Cancer Therapy

Epigenetic Cancer Therapy

Author : Steven Gray
Publisher : Academic Press
Genre : Medical
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Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the ...

Epigenetic Mechanisms in Cancer

Epigenetic Mechanisms in Cancer

Author : Sabita Saldanha
Publisher : Academic Press
Genre : Medical
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Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences ...

Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics

Author : Gerda Egger,Paola Arimondo
Publisher : Academic Press
Genre : Medical
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Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found ...

Cancer Epigenetics

Cancer Epigenetics

Author : Trygve Tollefsbol
Publisher : CRC Press
Genre : Science
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During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, ...

Epigenetic Therapy of Cancer

Epigenetic Therapy of Cancer

Author : Michael Lübbert,Peter A. Jones
Publisher : Springer Science & Business Media
Genre : Medical
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The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA ...

Epigenetics in Human Disease

Epigenetics in Human Disease

Author : Trygve O. Tollefsbol
Publisher : Academic Press
Genre : Medical
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Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of ...

Epigenetics of Cancer Prevention

Epigenetics of Cancer Prevention

Author : Anupam Bishayee,Deepak Bhatia
Publisher : Academic Press
Genre : Medical
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Epigenetics of Cancer Prevention, Volume Ten is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, together they will set ...

Introduction to Epigenetics

Introduction to Epigenetics

Author : Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
Publisher : Springer Nature
Genre : Science
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This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, ...

Breast Cancer Metastasis and Drug Resistance

Breast Cancer Metastasis and Drug Resistance

Author : Aamir Ahmad
Publisher : Springer Nature
Genre : Medical
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Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current ...

Unravelling Cancer Signaling Pathways  A Multidisciplinary Approach

Unravelling Cancer Signaling Pathways A Multidisciplinary Approach

Author : Kakoli Bose,Pradip Chaudhari
Publisher : Springer Nature
Genre : Medical
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Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction ...

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation

Author : Suming Huang,Michael D Litt,C. Ann Blakey
Publisher : Academic Press
Genre : Science
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Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can ...

Human Skin Cancers

Human Skin Cancers

Author : Miroslav Blumenberg
Publisher : BoD – Books on Demand
Genre : Medical
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Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF ...

Cancer Epigenetics for Precision Medicine

Cancer Epigenetics for Precision Medicine

Author : Ramona G. Dumitrescu,Mukesh Verma
Publisher : Humana Press
Genre : Medical
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This volume discusses certain epigenetic changes recognized in early carcinogenic lesions and different tumors, as well as factors that alter the epigenome and epigenetic profile such as diet, alcohol, immunity, circadian rhythm, and more. The chapters in this book further delve into this field and cover topics such as epigenome-based ...

Cancer Epigenetics

Cancer Epigenetics

Author : Trygve Tollefsbol
Publisher : CRC Press
Genre : Uncategorized
Get Book

During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, ...

Gynaecological Malignancies

Gynaecological Malignancies

Author : Gwo Yaw Ho,Sophia Frentzas
Publisher : BoD – Books on Demand
Genre : Medical
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“Gynaecological Malignancies - Updates and Advances” aims to present a review of the significant advances in the understanding and management of gynaecological malignancies. Major areas of importance in this field will be covered, incorporating new knowledge that has arisen due to the advancements in molecular techniques and the ability to ...