Carbonic Anhydrases as Biocatalysts
  • Author : Claudiu T Supuran
  • Release Date : 14 January 2015
  • Publisher : Elsevier
  • Genre : Technology & Engineering
  • Pages : 398
  • ISBN 13 : 9780444632630

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Book excerpt: Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications

Carbonic Anhydrases as Biocatalysts

Carbonic Anhydrases as Biocatalysts

Author : Claudiu T Supuran,Giuseppina De Simone
Publisher : Elsevier
Genre : Technology & Engineering
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Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both ...

The Carbonic Anhydrases

The Carbonic Anhydrases

Author : W.R. Chegwidden,N.D. Carter,Y.H. Edwards
Publisher : Birkhäuser
Genre : Science
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Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), ...

Carbonic Anhydrases

Carbonic Anhydrases

Author : Claudiu T. Supuran,Alessio Nocentini
Publisher : Academic Press
Genre : Science
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Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction ...

The Carbonic Anhydrases

The Carbonic Anhydrases

Author : S.J. Dodgson,N.D. Carter,G. Gros,R.E. Tashian
Publisher : Springer Science & Business Media
Genre : Science
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As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family ...

Carbonic Anhydrase  Mechanism  Regulation  Links to Disease  and Industrial Applications

Carbonic Anhydrase Mechanism Regulation Links to Disease and Industrial Applications

Author : Susan C. Frost,Robert McKenna
Publisher : Springer Science & Business Media
Genre : Medical
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The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA ...

The Carbonic Anhydrases  Current and Emerging Therapeutic Targets

The Carbonic Anhydrases Current and Emerging Therapeutic Targets

Author : W. Richard Chegwidden,Nicholas D. Carter
Publisher : Springer Nature
Genre : Medical
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This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both ...

Carbonic Anhydrase

Carbonic Anhydrase

Author : Claudiu T. Supuran,Andrea Scozzafava,Janet Conway
Publisher : CRC Press
Genre : Medical
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Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of in...

Diseases of the Kidney and Urinary Tract

Diseases of the Kidney and Urinary Tract

Author : Robert W. Schrier
Publisher : Lippincott Williams & Wilkins
Genre : Medical
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The thoroughly updated Eighth Edition of this classic three-volume work provides the most comprehensive, current, and authoritative information on diseases of the kidney and urinary tract. This clinically oriented reference focuses on diagnosis and treatment of specific diseases, disorders, and complications and incorporates the basic science practicing physicians need to ...

Carbonic Anhydrases and Metabolism

Carbonic Anhydrases and Metabolism

Author : Claudiu T. Supuran
Publisher : MDPI
Genre : Science
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Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also ...

Carbonic Anhydrase as Drug Target

Carbonic Anhydrase as Drug Target

Author : Daumantas Matulis
Publisher : Springer
Genre : Science
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This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their ...

The Anatomical Record

The Anatomical Record

Author : Charles Russell Bardeen,Irving Hardesty,John Lewis Bremer,Edward Allen Boyden
Publisher : Unknown
Genre : Anatomy
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Issues for 1906- include the proceedings and abstracts of papers of the American Association of Anatomists (formerly the Association of American Anatomists); 1916-60, the proceedings and abstracts of papers of the American Society of Zoologists....

Carbonic Anhydrase as Drug Target

Carbonic Anhydrase as Drug Target

Author : Daumantas Matulis
Publisher : Springer
Genre : Science
Get Book

This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their ...

An Innovative Approach to Understanding and Treating Cancer  Targeting pH

An Innovative Approach to Understanding and Treating Cancer Targeting pH

Author : Tomas Koltai,Stephan J. Reshkin,Salvador Harguindey
Publisher : Academic Press
Genre : Science
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An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of ...