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Between the Lines of Genetic Code
  • Author : Leonid Padyukov
  • Release Date : 28 September 2013
  • Publisher : Elsevier Inc. Chapters
  • Genre : Science
  • Pages : 232
  • ISBN 13 : 9780128061749
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Between the Lines of Genetic Code

Between the Lines of Genetic Code

Author : Leonid Padyukov
Publisher : Academic Press
Genre : Science
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Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs ...

Between the Lines of Genetic Code

Between the Lines of Genetic Code

Author : Leonid Padyukov
Publisher : Unknown
Genre : Science
Get Book

Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs ...

Between the Lines of Genetic Code

Between the Lines of Genetic Code

Author : Jesper Tegnér,Francesco Marabita,David Gomez-Cabrero
Publisher : Elsevier Inc. Chapters
Genre : Science
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Following the success of genome-wide association studies, it is now important to unravel interactions between genes as well as between genes and environment. Here we discuss how to interpret higher order statistical interactions in terms of underlying biological processes purportedly generating such dependencies. In this chapter, we specifically review how ...

Between the Lines of Genetic Code

Between the Lines of Genetic Code

Author : Klementy Shchetynsky,Leonid Padyukov
Publisher : Elsevier Inc. Chapters
Genre : Science
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Functional analysis of genetic variants in association with human complex diseases remains a challenge for modern research. Discovery of gene–gene interactions may represent an additional tool for identifying specific polymorphisms involved in disease development. It not only identifies new candidate genes for mechanistic studies, but also suggests biological relations ...

Between the Lines of Genetic Code

Between the Lines of Genetic Code

Author : Bo Ding
Publisher : Elsevier Inc. Chapters
Genre : Science
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Genome-wide interaction studies is an extremely challenging problem in statistics, in which conventional methods are often inadequate in terms of both power and computational efficiency. An exhaustive search for genome-wide gene–gene interactions becomes feasible with modern cluster computing run on graphics processing units. However, the large number of tests ...

Between the Lines of Genetic Code

Between the Lines of Genetic Code

Author : Marylyn D. Ritchie
Publisher : Elsevier Inc. Chapters
Genre : Science
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Gene–gene interactions are a critical component of the genetic architecture of complex, human traits. Unfortunately, the detection and characterization of interactions is a challenge. This is due to a number of factors including the combinatorial explosion of possible interactions in large-scale genomic data, limited power in small sample sizes, ...

Between the Lines of Genetic Code

Between the Lines of Genetic Code

Author : Camilla Bengtsson,Henrik Källberg
Publisher : Elsevier Inc. Chapters
Genre : Science
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Many diseases are believed to occur as a result of interactions between genes and environment. In epidemiology, there are several study designs, such as cohort and case-control studies, that can be used to analyze biological interaction. In this chapter, we discuss crucial issues in the design stage of epidemiologic studies, ...

Between the Lines of Genetic Code

Between the Lines of Genetic Code

Author : Ingrid Kockum,Lars Alfredsson,Tomas Olsson
Publisher : Elsevier Inc. Chapters
Genre : Science
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Multiple sclerosis (MS) is a multifactorial disease where both environmental and genetic risk factors play a role. More than 50 genetic polymorphisms have been identified in association with MS mostly by mapping close to genes involved in immunoregulation. Several environmental factors have been associated with risk for developing MS, including smoking, ...

Mapping and Sequencing the Human Genome

Mapping and Sequencing the Human Genome

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Publisher : National Academies Press
Genre : Science
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There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies ...

Between the Lines of Genetic Code

Between the Lines of Genetic Code

Author : Leonid Padyukov,Lars Alfredsson
Publisher : Elsevier Inc. Chapters
Genre : Science
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Rheumatoid arthritis (RA) is a chronic autoimmune disease with poorly understood etiology. Over the years, many genetic risk factors and some environmental risk factors were discovered to be important for RA. Genetic variants from the HLA-DRB1 locus, the shared epitope alleles, in different populations show a relatively strong and consistent ...

Between the Lines of Genetic Code

Between the Lines of Genetic Code

Author : Henrik Källberg,Camilla Bengtsson
Publisher : Elsevier Inc. Chapters
Genre : Science
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This chapter deals with estimation of interaction through different statistical models. Interaction is classified into two different classes, antagonistic and synergistic effects. An antagonistic effect is said to be present if the combination of two factors decrease the measure of interest as compared to the expected sum of the single ...

Between the Lines of Genetic Code

Between the Lines of Genetic Code

Author : Igor Sandalov,Leonid Padyukov
Publisher : Elsevier Inc. Chapters
Genre : Science
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We introduce new quantitative characteristics of the population using an analogy to the system of multi-spin molecules: the disease fields, which may depend on interactions, and the susceptibility to disease as derivative of genetic vector’s (GV’s) frequency of cases with respect to these fields. The genetic vector’s ...

Stop Codon Reassignment in the Wild

Stop Codon Reassignment in the Wild

Author : Anonim
Publisher : Unknown
Genre : Uncategorized
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Since the discovery of the genetic code and protein translation mechanisms (1), a limited number of variations of the standard assignment between unique base triplets (codons) and their encoded amino acids and translational stop signals have been found in bacteria and phages (2-3). Given the apparent ubiquity of the canonical genetic ...