Basics of Chimeric Antigen Receptor (CAR) Immunotherapy
  • Author : Mumtaz Y. Balkhi
  • Release Date : 31 July 2019
  • Publisher : Academic Press
  • Genre : Medical
  • Pages : 92
  • ISBN 13 : 9780128197479

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Book excerpt: Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field. Presents the first book to provide a basic understanding of chimeric antigen receptor (CARs) design, production and clinical application protocols Provides unique authority as the editor has worked directly with CARs Discusses the challenges encountered in actual clinical trials and how these challenges can be overcome Includes a full chapter on various challenges researchers should expect to encounter in the CAR-therapy field

Basics of Chimeric Antigen Receptor  CAR  Immunotherapy

Basics of Chimeric Antigen Receptor CAR Immunotherapy

Author : Mumtaz Y. Balkhi
Publisher : Academic Press
Genre : Medical
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Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope ...

Chimeric Antigen Receptor T Cell Therapies for Cancer E Book

Chimeric Antigen Receptor T Cell Therapies for Cancer E Book

Author : Daniel W. Lee,Nirali N. Shah
Publisher : Elsevier Health Sciences
Genre : Medical
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From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali ...

Chimeric Antigen Receptor T Cells

Chimeric Antigen Receptor T Cells

Author : Kamilla Swiech,Kelen Cristina Ribeiro Malmegrim,Virgínia Picanço-Castro
Publisher : Humana
Genre : Medical
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This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful ...

Part I  Understanding Cancer Immunotherapy  A brief Review  Part II     What is Chimeric Antigen Receptor  CAR  T  Cell Therapy     An Emerging Cancer Treatment Modality

Part I Understanding Cancer Immunotherapy A brief Review Part II What is Chimeric Antigen Receptor CAR T Cell Therapy An Emerging Cancer Treatment Modality

Author : Dr. Hakim Saboowala
Publisher : Dr.Hakim Saboowala
Genre : Medical
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Part I- Understanding Cancer Immunotherapy: A brief Review. Immunotherapy, also called biologic therapy, is a type of cancer treatment that boosts the body's natural defenses to fight cancer. It uses substances made by the body or in a laboratory to improve or restore immune system function. Immunotherapy may work by: ...

Fast Facts  CAR T Cell Therapy

Fast Facts CAR T Cell Therapy

Author : R.J. Buka,A.J. Kansagra
Publisher : Karger Medical and Scientific Publishers
Genre : Medical
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Chimeric antigen receptor (CAR) T cells are genetically engineered immune cells that can seek out and destroy cancer cells. The results from their use in cancer immunotherapy have been very promising, but treatment is often associated with frequent, serious short-term toxicities. 'Fast Facts: CAR-T Therapy' explains what CAR T cells ...

Protein Engineering

Protein Engineering

Author : Huimin Zhao
Publisher : John Wiley & Sons
Genre : Science
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A one-stop reference that reviews protein design strategies to applications in industrial and medical biotechnology Protein Engineering: Tools and Applications is a comprehensive resource that offers a systematic and comprehensive review of the most recent advances in the field, and contains detailed information on the methodologies and strategies behind these ...

Stem Cells     From Hype to Real Hope

Stem Cells From Hype to Real Hope

Author : Khawaja Husnain Haider,Salim Aziz, MD
Publisher : Walter de Gruyter GmbH & Co KG
Genre : Medical
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This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting ...

Immunotherapy

Immunotherapy

Author : Krassimir Metodiev
Publisher : BoD – Books on Demand
Genre : Medical
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This is another attempt of InTechOpen to continue the dissemination of international knowledge and experience in the field of immunology. The present book includes a number of modern concepts of specialists and experts in the field of immunotherapy, covering the major topics and analyzing the history, current stage, and future ...

Cancer Immunology and Immunotherapy

Cancer Immunology and Immunotherapy

Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Academic Press
Genre : Business & Economics
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Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) ...

Developments in T Cell Based Cancer Immunotherapies

Developments in T Cell Based Cancer Immunotherapies

Author : Paolo A. Ascierto,David F. Stroncek,Ena Wang
Publisher : Humana Press
Genre : Medical
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This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell ...

Tumor Microenvironment

Tumor Microenvironment

Author : Peter P. Lee,Francesco M. Marincola
Publisher : Springer Nature
Genre : Medical
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This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/...

Immunotherapy Using Chimeric Antigen Receptor Macrophage

Immunotherapy Using Chimeric Antigen Receptor Macrophage

Author : Peng Fei Huang
Publisher : Unknown
Genre : Uncategorized
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Chimeric antigen receptor (CAR) T cell immunotherapy has become one of the most prominent and leading cancer therapies due to its remarkable success in targeting hematological malignancies. Unfortunately, CAR-T cell immunotherapy has not had the same amount of success in solid tumors due to the challenging tumor's immunosuppressive microenvironment. Therefore, ...