Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi
  • Release Date : 16 April 2019
  • Publisher : Academic Press
  • Genre : Business & Economics
  • Pages : 470
  • ISBN 13 : 9780128147054

Download Or Read Animal Models in Cancer Drug Discovery eBook PDF

Book excerpt: Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery

Author : Asfar Azmi,Ramzi M. Mohammad
Publisher : Academic Press
Genre : Business & Economics
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Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on ...

Translational Animal Models in Drug Discovery and Development

Translational Animal Models in Drug Discovery and Development

Author : Xinkang Wang
Publisher : Bentham Science Publishers
Genre : Science
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Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene ...

Tumor Models in Cancer Research

Tumor Models in Cancer Research

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Genre : Medical
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The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the ...

Alternatives to Animal Testing

Alternatives to Animal Testing

Author : Hajime Kojima,Troy Seidle,Horst Spielmann
Publisher : Springer
Genre : Medical
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This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, ...

Unravelling Cancer Signaling Pathways  A Multidisciplinary Approach

Unravelling Cancer Signaling Pathways A Multidisciplinary Approach

Author : Kakoli Bose,Pradip Chaudhari
Publisher : Springer Nature
Genre : Medical
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Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction ...

   Humanized    Large Animal Cancer Models  Accelerating Time and Effectiveness of Clinical Trials

Humanized Large Animal Cancer Models Accelerating Time and Effectiveness of Clinical Trials

Author : Kyle M. Schachtschneider,Gregers Jungersen,Lawrence B. Schook,Dhanansayan Shanmuganayagam
Publisher : Frontiers Media SA
Genre : Uncategorized
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This eBook provides futuristic perspectives with respect to the emerging requirements of large animal cancer models to address unmet clinical needs. As the vast majority of drugs tested in small animal cancer models fail in human clinical trials, there is a need for large animal models to translate results obtained ...

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum
Publisher : National Academies Press
Genre : Medical
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Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking ...

In vivo Models for Drug Discovery

In vivo Models for Drug Discovery

Author : José Miguel Vela,Rafael Maldonado,Michel Hamon
Publisher : John Wiley & Sons
Genre : Medical
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This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on ...

Mouse Models for Drug Discovery

Mouse Models for Drug Discovery

Author : Gabriele Proetzel,Michael V. Wiles
Publisher : Humana
Genre : Medical
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As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse ...

Drug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy

Author : Kenneth K.W. To,William C.S. Cho
Publisher : Academic Press
Genre : Science
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Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for ...

Protocol Handbook for Cancer Biology

Protocol Handbook for Cancer Biology

Author : Gauri Misra,Jyotika Rajawat
Publisher : Academic Press
Genre : Science
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Protocol Handbook for Cancer Biology brings together a comprehensive collection of the methods used for cancer assessment, diagnostics, and therapeutics. Various protocols are discussed along with alternative strategies, including the advantages and limitations of techniques that have been used in labs globally. These protocols are presented by cancer biology experts ...

Phenotypic Drug Discovery

Phenotypic Drug Discovery

Author : Angelique Augustin,Beverley Isherwood
Publisher : Royal Society of Chemistry
Genre : Medical
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Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by ...

Animal Models for Human Cancer

Animal Models for Human Cancer

Author : Marianne I. Martic-Kehl,Pius August Schubiger
Publisher : John Wiley & Sons
Genre : Medical
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Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the ...

Mouse Models of Human Cancer

Mouse Models of Human Cancer

Author : Eric C. Holland
Publisher : Wiley-Liss
Genre : Science
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Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize ...

Good Research Practice in Non Clinical Pharmacology and Biomedicine

Good Research Practice in Non Clinical Pharmacology and Biomedicine

Author : Anton Bespalov,Martin C. Michel,Thomas Steckler
Publisher : Springer Nature
Genre : Cardiology
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This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine....